Interesting ImagesHyoepiglottic Rheumatoid Nodule Mimicking Head and Neck Malignancy on 18F-FDG PET/CTOpalinski, Ludwig MD∗; Schmitz, Sandra MD, PhD†; Van Eeckhout, Pascal MD‡; d’Abadie, Philippe MD, PhD∗; Gheysens, Olivier MD, PhD∗ Author Information From the Departments of ∗Nuclear Medicine †Head and Neck Surgery ‡Pathology, Institut Roi Albert II, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. Received for publication May 24, 2022; revision accepted September 15, 2022. Conflicts of interest and sources of funding: none declared. Correspondence to: Ludwig Opalinski, MD, Department of Nuclear Medicine, Institut Roi Albert II, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 10 Avenue Hippocrate, 1200 Brussels, Belgium. E-mail: [email protected]. Clinical Nuclear Medicine 48(2):p e80-e81, February 2023. | DOI: 10.1097/RLU.0000000000004458 Buy Metrics Abstract A 54-year-old man with a history of tonsillar squamous cell carcinoma treated with chemoradiotherapy and an 18-year history of seropositive rheumatoid arthritis in remission without maintenance therapy presented with right cervical pain and dysphagia for several months. Flexible laryngoscopy did not show any lesion, and MRI revealed a necrotic lesion inside the thyro-hyo-epiglottic space attached to the hyoid bone. 18F-FDG PET/CT demonstrated a moderately increased metabolic activity of the lesion without any other suspected lesions. Surgical resection was performed, and pathology revealed a necrotizing granuloma compatible with a rheumatoid nodule. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.