Interesting ImagesAortitis PET Imaging in VEXAS Syndrome A Case ReportGrambow-Velilla, Julia MD∗; Braun, Thorsten MD, PhD†; Pop, Gabriel MD∗; Louzoun, Astrid MD∗; Soussan, Michael MD, PhD∗ Author Information From the Departments of ∗Nuclear Medicine †Hematology, AP-HP Avicenne University Hospital, Bobigny, France. Received for publication May 10, 2022; revision accepted October 15, 2022. Conflicts of interest and sources of funding: none declared. Correspondence to: Michael Soussan, MD, PhD, Department of Nuclear Medicine, Hôpital Avicenne AP-HP, 25 Rue de Stalingrad, 93000 Bobigny, France. E-mail: [email protected]. Clinical Nuclear Medicine 48(2):p e67-e68, February 2023. | DOI: 10.1097/RLU.0000000000004506 Buy Metrics Abstract VEXAS (vacuoles, E1 enzyme, X-LINKED, autoinflammatory, somatic) syndrome is a complex inflammatory disease associated with somatic mutations of the ubiquitin-like modifier activating enzyme 1 (UBA1) gene. A 75-year-old man with a medical history of thrombophlebitis, leukocytoclastic vasculitis, chronic inflammatory arthralgia, elevated inflammatory markers, and anemia was diagnosed with VEXAS syndrome. 18F-FDG PET/CT showed thoracic aortitis, a rare involvement during VEXAS syndrome. Corticosteroid therapy monitored with 18F-FDG PET/CT led to a complete metabolic response. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.