Interesting ImagesPulmonary Artery Angiomatoid Fibrous Histiocytoma Mimicking a Large Pulmonary EmbolismHaug, Logan P. MD∗; Zarka, Matthew A. MD†; D’Cunha, Jonathan MD, PhD‡; Downey, Francis X. III MD‡; Seetharam, Mahesh MD§; Yang, Ming MD∗ Author Information From the ∗Department of Radiology †Laboratory Medicine and Pathology ‡Cardiothoracic Surgery §Hematology/Oncology Mayo Clinic Arizona, Scottsdale, AZ. Received for publication March 22, 2022; revision accepted May 3, 2022. Conflicts of interest and sources of funding: none declared. Correspondence to: Ming Yang, MD, Nuclear Radiology, Department of Radiology, Mayo Clinic in Arizona, 13400 E Shea Blvd, Scottsdale, AZ 85259. E-mail: [email protected]. Clinical Nuclear Medicine: December 2022 - Volume 47 - Issue 12 - p e738-e739 doi: 10.1097/RLU.0000000000004306 Buy Metrics Abstract A 39-year-old man presented with progressive dyspnea and lower extremity edema. Doppler ultrasound demonstrated bilateral leg partially occluded venous thromboses. A V/Q scan revealed a mismatched perfusion defect involving the entire right middle and lower lobes. Subsequent CT pulmonary angiogram revealed a mass lesion occluding the right interlobar pulmonary artery. Endobronchial ultrasound–guided fine-needle aspiration of the mass was concerning for neoplasm. 18F-FDG PET/CT demonstrated marked hypermetabolism of the mass lesion. Patient underwent transmediastinal right pneumonectomy with histopathologic diagnosis of pulmonary artery angiomatoid fibrous histiocytoma, a rare etiology mimicking large pulmonary artery embolism. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.