Interesting ImagesHypermetabolic Esophagitis Dessicans Superficialis Mimicking Esophageal Cancer on FDG PET/CTMamaliga, Tatiana MD; Liu, Yiyan MD, PhD Author Information From the Department of Radiology, University of Louisville School of Medicine, Louisville, KY. Received for publication April 1, 2022; revision accepted May 4, 2022. Conflicts of interest and sources of funding: none declared. Correspondence to: Yiyan Liu, MD, PhD, Department of Radiology, University of Louisville Hospital, 500 S Jackson St, Louisville, KY 40202. E-mail: [email protected]. Clinical Nuclear Medicine: December 2022 - Volume 47 - Issue 12 - p 1069-1070 doi: 10.1097/RLU.0000000000004303 Buy Metrics Abstract An 83-year-old man with history of multiple myeloma obtained an FDG PET/CT for surveillance. Although there was no evidence of metabolically active myeloma, an incidental highly FDG-avid focus was noted at the gastroesophageal junction. Findings were interpreted as malignancy. The patient underwent esophagogastroduodenoscopy, which showed nonerythematous desquamation of the distal esophagus consistent with esophagitis dessicans superficialis (EDS) without any evidence of malignancy. There is paucity of literature regarding EDS and its image findings. This case illustrates an instance of focal mass-like uptake on FDG PET/CT, which represents an endoscopy- and pathology-confirmed EDS and mimics esophageal cancer. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.