Interesting ImagesThe Onset of Sarcoidosis After COVID-19 Vaccination Revealed by the 18F-FDG PETSong, Xiangming MD; Shao, Fuqiang MD, PhD; Lan, Xiaoli MD, PhD Author Information From the Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Hubei Key Laboratory of Molecular Imaging; and Key Laboratory of Biological Targeted Therapy, the Ministry of Education, Wuhan, China. Received for publication May 20, 2022; revision accepted June 23, 2022. Conflicts of interest and sources of funding: none declared. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the principles of the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Written informed consent was obtained from the patient for publication. Correspondence to: Xiaoli Lan, MD, PhD, No. 1277 Jiefang Ave, Wuhan 430022, Hubei Province, China. E-mail: [email protected]. Clinical Nuclear Medicine: October 2022 - Volume 47 - Issue 10 - p 869-871 doi: 10.1097/RLU.0000000000004352 Buy Metrics Abstract Sarcoidosis is a heterogeneous multisystem disease characterized by noncaseating granulomas. We presented 18F-FDG PET/CT findings of sarcoidosis in a previously healthy 43-year-old man who presented intermittent cough after the third dose of COVID-19 vaccination. 18F-FDG PET/CT showed high uptake of one solitary nodule in the right middle lobe, mediastinal lymph nodes, bilateral hila, and multiple nodules under the right pleura, mimicking the malignancy. Nevertheless, the biopsy confirmed distinct noncaseating granulomas. This case emphasizes the onset of sarcoidosis revealed by 18F-FDG PET/CT after COVID-19 vaccination. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.