Interesting ImagesFalse-Positive 18F–Prostate-Specific Membrane Antigen–1007 PET/CT Caused by Hepatic Multifocal Inflammatory FociLadrón-de-Guevara, David MD∗,†; Canelo, Alejando MD‡; Piottante, Antonio MD§; Regonesi, Carlos MD∥Author Information From the ∗Department of Radiology, Clínica Las Condes †School of Medicine, Universidad de Chile ‡Pontificia Universidad Católica de Chile Departments of §Pathology ∥Oncology, Clínica Las Condes, Santiago, Chile. Received for publication April 23, 2020; revision accepted October 12, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: David Ladrón-de-Guevara, MD, Radiology Department, Clínica Las Condes, Estoril 450, Las Condes, Santiago, Chile. E-mail: [email protected]. Clinical Nuclear Medicine: February 2021 - Volume 46 - Issue 2 - p e80-e83 doi: 10.1097/RLU.0000000000003425 Buy Metrics Abstract A 68-year-old man with history of treated prostate cancer was referred to 68Ga–prostate-specific membrane antigen (PSMA)–11 PET/CT imaging. Moderate bone involvement was observed, with a normal liver tracer uptake. Bone biopsy confirmed metastases of prostate cancer. After therapy adjustment, a follow-up 18F-PSMA-1007 PET/CT revealed good response in bone lesions, although it showed 3 new rounded liver intense uptake foci. Concurrent PSA was 0.6 ng/mL. Liver function tests were normal. PET/CT-guided hepatic biopsy demonstrated no malignant cells, focal inflammation, and steatosis, being possibly the inflammation the cause of false-positive multifocal uptake of 18F-PSMA-1007. Following PET/CT, controls showed a normal liver. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.