Interesting ImagesBilateral Silicone Granulomas Mimicking Breast Cancer Recurrence on 18F-FDG PET/CTFernandes Vieira, Victor MD∗; Dubruc, Estelle MD†; Raffoul, Wassim MD‡; Prior, John O. MD, PhD∗; Meyer, Marie MD, PhD∗Author Information From the ∗Nuclear Medicine and Molecular Imaging Department †Pathology Department ‡Plastic Surgery Department, Lausanne University Hospital, Lausanne, Switzerland. Received for publication June 16, 2020; revision accepted October 9, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: John O. Prior, MD, PhD, Nuclear Medicine Department, CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland. E-mail: [email protected]. Clinical Nuclear Medicine: February 2021 - Volume 46 - Issue 2 - p 140-141 doi: 10.1097/RLU.0000000000003422 Buy Metrics Abstract We report the case of a 45-year-old woman with a history of right breast reconstruction with silicone implant for breast cancer. An 18F-FDG PET/CT performed several years later revealed the presence of 18F-FDG–avid nodules at the periphery of the silicone implant, in the right internal mammary chain, and in the contralateral breast. Needle core biopsies were positive for bilateral silicone granulomas, without any sign of malignancy. This case displays intense 18F-FDG uptake in silicone granulomas affecting the contralateral breast after implant reconstruction. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.