Interesting ImagesAdvantage of 68Ga-PSMA PET/CT on Postradiotherapy Response Assessment of Juvenile Nasal AngiofibromaSakthivel, Pirabu MS, DNB∗; Thakar, Alok MS, FRCS∗; Thankarajan Arunraj, Sreedharan MD†; Bhalla, Ashu Seith MD‡; Kumar, Rakesh MD†Author Information From the Departments of ∗Otorhinolaryngology and Head and Neck Surgery †Nuclear Medicine ‡Radiology, All India Institute of Medical Sciences, New Delhi, India. Received for publication June 11, 2020; revision accepted September 12, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Rakesh Kumar, MD, Division of Diagnostic Nuclear Medicine, Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi 110029, India. E-mail: [email protected]. Clinical Nuclear Medicine: February 2021 - Volume 46 - Issue 2 - p e123-e124 doi: 10.1097/RLU.0000000000003359 Buy Metrics Abstract Prostate-specific membrane antigen (PSMA) is universally expressed in the endothelial cells of tumor-associated neovasculature of juvenile nasopharyngeal angiofibroma. Functional 68Ga-PSMA PET/CT also enables easier differentiation of the residual tumor from postoperative changes. An 18-year-old man with the residual intracranial disease received radiotherapy after surgery. In PSMA PET/CT imaging, uptake was noted initially only in the residual disease, and the same was absent after successful response to radiotherapy, unlike contrast MRI, which showed persistent enhancement. Functional 68Ga-PSMA PET/CT may be a very useful tool clinically for identifying early responses to radiotherapy compared with conventional structural imaging. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.