Interesting ImagesWidespread Skin Infiltration of Leukemia Cutis on 18F-FDG PET/CTZheng, Jieling MD; Xue, Qianqian MD; Lin, Kaixian MD; Miao, Weibing MD, PhDAuthor Information From the Department of Nuclear Medicine, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China. Received for publication February 25, 2020; revision accepted April 22, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Weibing Miao, MD, PhD, Department of Nuclear Medicine, First Affiliated Hospital of Fujian Medical University, No. 20, Chazhong Rd, Fuzhou, 350005, Fujian, China. E-mail: firstname.lastname@example.org. Clinical Nuclear Medicine: November 2020 - Volume 45 - Issue 11 - p e489-e490 doi: 10.1097/RLU.0000000000003131 Buy Metrics Abstract A 67-year-old man experienced multiple cutaneous nodules for 3 weeks. His initial skin biopsy only showed local inflammation. However, after a 2-week anti-inflammation therapy, the skin manifestations were not improved while the leukocyte count gradually increased. FDG PET/CT revealed widespread cutaneous and subcutaneous hypermetabolic lesions in many parts of the body, and heterogeneously increased uptakes in the bone marrow. Bone marrow biopsy and second skin biopsy were performed. Pathological examination from both specimen demonstrated acute monocytic leukemia. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.