Interesting ImagesIncidental Detection of Malignant Melanoma Brain Recurrence on 68Ga–Prostate-Specific Membrane Antigen PET/CTHod, Nir MHA, MD∗; Lantsberg, Sophie MD∗; Benkovich, Elya MD†; Kazap, Dina Ezroh MD∗; Preiskel, Mark MD∗; Levin, Daniel MD∗Author Information From the ∗Institute of Nuclear Medicine and Molecular Imaging †MRI Unit of the Diagnostic Imaging Department, Soroka University Medical Center, Beer-Sheva, Israel, Affiliated to Ben Gurion University of the Negev, Faculty of Health Sciences. Conflicts of interest and sources of funding: none declared. Received for publication April 20, 2020; revision accepted June 1, 2020. Correspondence to: Nir Hod, MHA, MD, Institute of Nuclear Medicine and Molecular Imaging, Soroka University Medical Center, Rager Boulevard, PO Box 151, Beer-Sheva, 84101, Israel. E-mail: [email protected]. Clinical Nuclear Medicine: November 2020 - Volume 45 - Issue 11 - p 896-899 doi: 10.1097/RLU.0000000000003216 Buy Metrics Abstract A 76-year-old man with a prior medical history of resected malignant melanoma of the skull underwent 68Ga–prostate-specific membrane antigen (PSMA) PET/CT due to rising tumor markers of a known prostate carcinoma. Unexpected high 68Ga-PSMA brain uptake was encountered around the surgical cavity in the skull with initially no specific structural changes on anatomical imaging. Successive CT and MRI eventually revealed local melanoma brain recurrence at this site. This interesting case demonstrates the diagnostic potential of 68Ga-PSMA PET/CT imaging for detection of malignant melanoma brain recurrence. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.