Interesting ImagesGraft-Versus-Host Disease Presenting as a Myositis and MyonecrosisPatel, Dhruv M. MD∗; Newallo, Domnique S. MD∗; Barron, Bruce MD, MHA∗,†Author Information From the ∗Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University †Veterans Administration Medical Center, Atlanta, GA. Received for publication March 10, 2020; revision accepted May 28, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Domnique S. Newallo, MD, Division of Nuclear Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, Atlanta, GA 30322. E-mail: [email protected]. Clinical Nuclear Medicine: November 2020 - Volume 45 - Issue 11 - p e495-e497 doi: 10.1097/RLU.0000000000003201 Buy Metrics Abstract Graft-versus-host disease (GVHD) is a major complication of bone marrow transplantation. Polymyositis with myonecrosis is a rare manifestation of GVHD. Here, we report the case of a 32-year-old man with acute myeloid leukemia who developed GVHD after transplant. He subsequently developed polymyositis, which was diagnosed on PET/CT and confirmed on pathology. Treatment with corticosteroids resulted in the resolution of the symptoms. Abnormal muscular FDG uptake resolved on the follow-up PET/CT. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.