Interesting ImagesFeasibility of 177Lu Therapy Monitoring Using Fast Whole-Body SPECT Recordings Provided by a High-Speed 360° CZT CameraChevalier, Elodie MD∗; Boursier, Caroline MD∗; Claudin, Marine MD∗; Marie, Pierre-Yves MD, PhD∗,†,‡; Imbert, Laetitia PhD∗,†,§Author Information From the ∗Nuclear Medicine Department †Nancyclotep Imaging Platform, CHRU-Nancy ‡INSERM, UMR-1116 §INSERM, UMR-1254, Université de Lorraine, Nancy, France. Received for publication March 7, 2020; revision accepted May 9, 2020. Informed consent was obtained from the participant included in this study. Conflicts of interest and sources of funding: none declared. Correspondence to: Laetitia Imbert, PhD, Médecine Nucléaire, Hôpital de Brabois, CHRU-Nancy, Allée du Morvan, 54500 Vandœuvre-lès-Nancy, France. E-mail: [email protected]. Clinical Nuclear Medicine: November 2020 - Volume 45 - Issue 11 - p e493-e494 doi: 10.1097/RLU.0000000000003169 Buy Metrics Abstract The whole-body absolute quantification of 177Lu-DOTATATE therapy was achieved using a high-speed 360° CZT SPECT/CT system. Twelve high-resolution swelling detectors may be positioned close to patients, providing a high-count sensitivity that is particularly advantageous for the low-count rate conditions of 177Lu imaging. After initially validating 177Lu quantification on phantom, serial whole-body SPECT/CT acquisitions of only 20 minutes were obtained for a 70-year-old woman treated by 177Lu-DOTATATE injections for a metastatic recurrence of a pancreatic neuroendocrine tumor. The progressive decrease in tumor uptake between the consecutive 177Lu-DOTATATE injections could be quantified, and thereby the corresponding dosimetry changes could be estimated. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.