Interesting ImagesExtramedullary Myeloma of the Uterus on 18F-FDG PET/CT A Rare Manifestation of Multiple MyelomaCausa Andrieu, Pamela Ines MD; Das, Jeeban Paul MD; Woo, Sungmin MD; Ryan, Reddy MD; Akin, Oguz MD; Ulaner, Gary A. MD, PhDAuthor Information From the Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY. Received for publication March 10, 2020; revision accepted May 12, 2020. Conflicts of interest and sources of funding: G.A.U. is a consultant to Sanofi. Correspondence to: Pamela Ines Causa Andrieu, MD, Comprehensive MRI Oncologic Imaging Fellowship, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10065. E-mail: firstname.lastname@example.org. Clinical Nuclear Medicine: November 2020 - Volume 45 - Issue 11 - p 873-875 doi: 10.1097/RLU.0000000000003179 Buy Metrics Abstract Involvement of the uterus by myeloma is an extremely rare manifestation of extramedullary multiple myeloma (MM), denoting a poor prognosis. Extramedullary MM occurs in 7% to 18% of newly diagnosed patients with MM, and 6% to 20% of patients can develop it later. We present a case of extramedullary MM of the uterus suspected on 18F-FDG PET/CT as a site of disease recurrence in a 47-year-old woman previously in remission. Further evaluation with pelvic MRI identified an infiltrative process involving the uterus, and subsequent tissue sampling confirmed malignant plasma cell infiltration of the uterus. This case highlights a rare site of myeloma recurrence, which can be detected by 18F-FDG PET/CT. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.