Interesting Images18F-THK5351 PET Can Identify Lesions of Acute Traumatic Brain InjuryTakami, Yasukage MD, PhD∗; Yamamoto, Yuka MD, PhD∗; Norikane, Takashi MD, PhD∗; Mitamura, Katsuya MD, PhD∗; Hatakeyama, Tetsuhiro MD, PhD†; Nishiyama, Yoshihiro MD, PhD∗Author Information From the Departments of ∗Radiology †Neurological Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan. Received for publication March 2, 2020; revision accepted May 11, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Yasukage Takami, MD, PhD, Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. E-mail: [email protected]. Clinical Nuclear Medicine: November 2020 - Volume 45 - Issue 11 - p e491-e492 doi: 10.1097/RLU.0000000000003165 Buy Metrics Abstract A 67-year-old woman sustained a mild traumatic brain injury (TBI) in a traffic accident and had an initial Glasgow Coma Scale score of 13. She underwent 18F-THK5351 PET 18 days after TBI. Fused 18F-THK5351 PET/MRI showed that the location of 18F-THK5351 accumulations corresponded anatomically to intraparenchymal lesions of acute TBI on MRI. 18F-THK5351 reportedly binds to monoamine oxidase B highly expressed in astrocytes. Furthermore, TBI induces reactive astrogliosis or blood-brain barrier breakdown included in primary brain injury. Therefore, 18F-THK5351 uptake may represent primary brain injury in acute TBI lesions. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.