Interesting ImagesIncidental Metastatic Melanoma Identified on 18F-FDOPA PET/CT With Confirmation by HistologyZhang-Yin, Jules MD∗; Jublanc, Christel MD†; Aouidad, Iman MD‡; Montravers, Françoise MD, PhD∗; Talbot, Jean-Noël MD, PhD∗Author Information From the ∗Department of Nuclear Medicine, Hôpital Tenon & Sorbonne Université †Department of Endocrinology and Cardiovascular Prevention, Hôpital Pitié Salpêtrière & Sorbonne Université, Paris ‡Department of Dermatology, Hôpital Ambroise Paré, Boulogne-Billancourt, France. Received for publication May 6, 2020; revision accepted June 20, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Jules Zhang-Yin, MD, Department of Nuclear Medicine, Hôpital Tenon & Sorbonne Université, 4 Rue de la Chine, 75020, Paris, France. E-mail: firstname.lastname@example.org. Clinical Nuclear Medicine: October 2020 - Volume 45 - Issue 10 - p 817-818 doi: 10.1097/RLU.0000000000003233 Buy Metrics Abstract A 47-year-old woman with a history of surgically treated abdominal paraganglioma and left thigh melanoma underwent an 18F-FDOPA PET/CT for suspected locoregional recurrence of paraganglioma. 18F-FDOPA PET/CT disconfirmed this recurrence but revealed 2 FDOPA-avid left inguinal lymph nodes, confirmed on a subsequent 18F-FDG PET/CT. Excision and pathology characterized these lymph nodes as melanoma metastases. 18F-FDOPA PET/CT is a widely used and valuable tool in the assessment of paraganglioma, both for staging and recurrence detection. Uptake of FDOPA has only rarely been documented in metastatic melanoma that could be a pitfall for detecting neuroendocrine tumors. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.