Interesting ImagesDiffuse Increased 68Ga-DOTATATE But Unimpressive 18F-FDG Osseous Activity in a Patient With Rapid-Progressing Synchronous Multifocal OsteosarcomaQin, Chunxia MD, PhD; Shao, Fuqiang MS; Lan, Xiaoli MD, PhDAuthor Information From the Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; and Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China. Received for publication May 19, 2020; revision accepted June 18, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Xiaoli Lan, MD, PhD, Department of Nuclear Medicine, Wuhan Union Hospital, No. 1277 Jiefang Ave, Wuhan, Hubei Province 430022, China. E-mail: firstname.lastname@example.org; LXL730724@hotmail.com. Clinical Nuclear Medicine: October 2020 - Volume 45 - Issue 10 - p 824-826 doi: 10.1097/RLU.0000000000003228 Buy Metrics Abstract Osteosarcoma is usually 18F-FDG–avid. Here we report a case of an 18-year-old young man with widespread osteoblastic and slight osteolytic changes, which had diffusely increased 68Ga-DOTATATE uptake in the osseous lesions, whereas the 18F-FDG PET/CT was unrevealing. The final diagnosis is synchronous multifocal osteosarcoma based on the pathological, clinical, and imaging features. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.