Interesting ImagesAbsent 18F-FDG Uptake in the Brain—Unsuspected Brain DeathPedersen, Mette Abildgaard MD∗,†,‡; Jensen-Fangel, Søren MD, DSc§; Nielsen, Edith MD∥; Borghammer, Per MD, PhD, DMSc∗; Vendelbo, Mikkel Holm MD, PhD∗,†Author Information From the ∗Department of Nuclear Medicine & PET Centre, Aarhus University Hospital †Department of Biomedicine, Aarhus University ‡Steno Diabetes Center Aarhus Departments of §Infectious Diseases ∥Neuroradiology, Aarhus University Hospital, Aarhus, Denmark. Received for publication January 16, 2020; revision accepted June 26, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Mikkel Holm Vendelbo, MD, PhD, Department of Nuclear Medicine & PET Centre, Palle Juul-Jensens Boulevard 165, Entrance J, J220, 8200 Aarhus N, Denmark. E-mail: email@example.com. Clinical Nuclear Medicine: October 2020 - Volume 45 - Issue 10 - p e433-e434 doi: 10.1097/RLU.0000000000003237 Buy Metrics Abstract Brain death is the complete, irreversible cessation of brain function, including the capacity for brainstem, respiratory, and vegetative activities. It is a clinical diagnosis that can be supplemented with brain perfusion imaging. Absent cerebral blood flow can be visualized with CT angiography or perfusion scintigraphy. 18F-FDG PET/CT, visualizing glucose uptake, is another approach that has been shown to indicate brain death in small case series. We here present a case with unsuspected absent 18F-FDG uptake and thus no metabolic activity, in the brain. The patient was declared brain dead later the same day. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.