Interesting Images99mTc-MDP Bone Scintigraphy in Gaucher DiseaseKesim, Selin MD∗; Turoglu, Halil Turgut MD, MSc, FEBNM∗; Tutar, Engin MD†; Ozguven, Salih MD∗; Erdil, Tanju Yusuf MD∗Author Information From the Departments of ∗Nuclear Medicine †Pediatrics, Marmara University Istanbul Pendik Training and Research Hospital, Istanbul, Turkey. Received for publication February 16, 2020; revision accepted April 26, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Halil Turgut Turoglu, MD, MSc, FEBNM, Department of Nuclear Medicine, Marmara University Istanbul Pendik Training and Research Hospital, Muhsin Yazıcıoğlu St, TR-34899, Üstkaynarca, Pendik, Istanbul, Turkey. E-mail: firstname.lastname@example.org. Clinical Nuclear Medicine: October 2020 - Volume 45 - Issue 10 - p e455-e456 doi: 10.1097/RLU.0000000000003140 Buy Metrics Abstract In this case report, we present the bone scintigraphic findings of a 9-year-old boy with Gaucher disease who has a history of fractures to evaluate the extent of his osseous lesions. Gaucher disease is a genetic deficiency of lysosomal enzyme glucocerebrosidase, which results in the accumulation of glucocerebroside in the macrophages in the reticuloendothelial cells of the spleen, liver, and bone marrow. Most patients with type 1 Gaucher disease present a clinical or radiographic evidence of infiltrative bone disease. Lipid-filled macrophages called Gaucher cells infiltrate the bone marrow, leading to medullary expansion, diffuse osteoporosis, ischemic necrosis, and fractures. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.