Interesting Images68Ga-FAPI PET/CT in Assessment of Leptomeningeal Metastases in a Patient With Lung AdenocarcinomaHao, Bing MD∗; Wu, Jingxun MD†; Pang, Yizhen MD∗; Sun, Long MD, PhD∗; Chen, Haojun MD, PhD∗Author Information From the ∗Department of Nuclear Medicine and Minnan PET Center †Department of Medical Oncology, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, China. Received for publication April 9, 2020; revision accepted June 21, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Haojun Chen, MD, Department of Nuclear Medicine and Minnan PET Center, PhD, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, 55 Zhenhai Rd, Xiamen 361003, China. E-mail: email@example.com. Clinical Nuclear Medicine: October 2020 - Volume 45 - Issue 10 - p 784-786 doi: 10.1097/RLU.0000000000003231 Buy Metrics Abstract We presented a case of 64-year-old woman with pathologically diagnosed lung adenocarcinoma. Brain metastases were highly suspected due to the appearance of neurological symptoms. However, no abnormal finding in the brain was observed on 18F-FDG PET/CT. Contrast-enhanced MRI showed the presence of leptomeningeal metastases but with a negative cerebrospinal fluid analysis. For this reason, the patient underwent 68Ga-FAPI PET/CT, later fused with MRI scans that showed intense uptake of 68Ga-FAPI in leptomeningeal regions correspondent to the sites of gadolinium enhancement. This case highlights that 68Ga-FAPI would be promising for the identification of leptomeningeal involvement in patients with malignant disease. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.