Interesting Images18F-Fluciclovine Uptake in Acute AppendicitisAhn, Grace S. BS∗; Barsky, Andrew R. MD†; Galperin-Aizenberg, Maya MD‡; Vapiwala, Neha MD§; Pantel, Austin R. MD∗Author Information From the ∗Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology †Department of Radiation Oncology ‡Division of Nuclear Medicine and Clinical Molecular Imaging, Division of Cardiothoracic Imaging, Department of Radiology §Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA. Received for publication February 14, 2020; revision accepted May 31, 2020. Conflicts of interest and sources of funding: A.R.P. has received a consulting fee and travel/lodging fees from Blue Earth Diagnostics Ltd in the past. The other authors have none declared. Correspondence to: Austin R. Pantel, MD, Division of Nuclear Medicine and Clinical Molecular Imaging, Department of Radiology, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104. E-mail: Austin.Pantel@pennmedicine.upenn.edu. Clinical Nuclear Medicine: October 2020 - Volume 45 - Issue 10 - p e453-e454 doi: 10.1097/RLU.0000000000003210 Buy Metrics Abstract An 85-year-old man with biochemical recurrence of prostate cancer after prostatectomy was imaged with 18F-fluciclovine PET/CT. Images incidentally revealed 18F-fluciclovine uptake in a dilated appendix with associated fat stranding, suggestive of acute appendicitis. The patient was then questioned about abdominal symptoms, and he reported severe right lower quadrant pain. He then underwent laparoscopic appendectomy with pathology confirming acute appendicitis. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.