Interesting Images18F-FDG PET/MRI of Rhinosporidiosis of the Upper AirwaysCazzador, Diego MD∗; Cecchin, Diego MD†; Colangeli, Roberta MD∗; Crimì, Filippo MD‡; Emanuelli, Enzo MD∗Author Information From the ∗Unit of Otorhinolaryngology, Department of Neurosciences †Nuclear Medicine Unit, Department of Medicine ‡Radiology Unit, Department of Medicine, University of Padova, Padova, Italy. Received for publication February 21, 2020; revision accepted April 26, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Diego Cazzador, MD, Unit of Otorhinolaryngology, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128 Padova, Italy. E-mail: email@example.com. Clinical Nuclear Medicine: October 2020 - Volume 45 - Issue 10 - p e461-e462 doi: 10.1097/RLU.0000000000003138 Buy Metrics Abstract A 41-year-old man from South Asia presented with a several months’ history of unilateral nasal obstruction and bleeding. At nasal endoscopy, two strawberry-like, friable, polypoid masses in the upper airways were detected. The patient’s clinical trait was compatible with an infectious disease. 18F-FDG PET/MRI was performed to evaluate the disease extension. Two lesions occupying the nasal cavity and the nasopharynx, slightly hyperintense in T2-weighted sequences, with intense radiopharmaceutical uptake were evidenced. Endoscopic resection was performed with histopathologic diagnosis of rhinosporidiosis, a chronic granulomatous disease caused by Rhinosporidium seeberi. Although rare, rhinosporidiosis should be considered in the differential diagnoses of sinonasal hypermetabolic lesions. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.