Interesting Images18F-FDG PET/CT in Labrune SyndromeCuzzocrea, Marco MD∗; Florimonte, Luigia MD∗; Scola, Elisa MD†; Benti, Riccardo MD∗; Castellani, Massimo MD∗Author Information From the Departments of ∗Nuclear Medicine †Neuroradiology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy. Received for publication January 23, 2020; revision accepted May 23, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Marco Cuzzocrea, MD, Department of Nuclear Medicine, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy. E-mail: email@example.com. Clinical Nuclear Medicine: October 2020 - Volume 45 - Issue 10 - p e439-e440 doi: 10.1097/RLU.0000000000003199 Buy Metrics Abstract A 69-year-old woman presented with cognitive impairment related to attentive, executive, and mnemonic functions; progressive worsening of walking, speaking, writing, and reading ability; and double sphincter incontinence. Leukoencephalopathy, cystic lesions, and calcifications, suspected for Labrune syndrome, were observed at MRI and CT brain images. Generalized wave abnormalities were also visible at electroencephalogram. Functional brain imaging performed with 18F-FDG PET/CT demonstrated a decreased glucose metabolism in impaired brain regions, in accordance with MRI findings. Genetic testing confirmed a mutation of SNORD118. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.