Interesting ImagesPSMA Expression in the Neovasculature Associated With Rectal Adenocarcinoma A Potential Stromal Target for Nuclear TheranosticsSonni, Ida MD∗; Caron, Justin MD†; Kishan, Amar U. MD‡,§,∥; Muthusamy, V. Raman MD¶; Calais, Jeremie MD∗,‡,∥Author Information From the ∗Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology †Department of Pathology, David Geffen School of Medicine ‡Institute of Urologic Oncology §Department of Radiation Oncology, David Geffen School of Medicine ∥Jonsson Comprehensive Cancer Center ¶Vatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine, University of California, Los Angeles, CA. Received for publication September 4, 2019; revision accepted March 15, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Ida Sonni, MD, Ahmanson Translational Theranostics Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA. E-mail: email@example.com. Clinical Nuclear Medicine: July 2020 - Volume 45 - Issue 7 - p e309-e310 doi: 10.1097/RLU.0000000000003066 Buy Metrics Abstract We report the case of a 63-year-old man who underwent MRI and 68Ga-PSMA-11 PET/CT for biochemical recurrence localization after radical prostatectomy (serum PSA, 0.25 ng/mL) and describe the incidental discovery of a rectal adenocarcinoma. Immunohistochemical analysis showed PSMA staining in the tumor-associated neovasculature, but not in normal vasculature, or tumor cells. After surgical removal, he was treated with salvage radiotherapy to the postoperative prostate bed. This case example has several implications: the findings confirm the expression of PSMA in the tumor-associated neovasculature of a rectal cancer, nonprostate cancers’ stroma may represent a potentially relevant target for nuclear theranostics. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.