Interesting ImagesMetabolic Evolution of Brain Metastasis After Stereotactic Radiosurgery Mismatch Between F-DOPA and FDG PETCicone, Francesco MD, PhD∗,†; Carideo, Luciano MD‡; Villani, Veronica MD, PhD§; Scaringi, Claudia MD, PhD∥; Bozzao, Alessandro MD¶; Scopinaro, Francesco MD‡; Minniti, Giuseppe MD, PhD∥,∗∗,††Author Information From the ∗Unit of Nuclear Medicine, Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, Catanzaro, Italy †Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland ‡Unit of Nuclear Medicine, Sant’Andrea Hospital, Department of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome §Neuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute ∥Radiation Oncology Unit, UPMC Hillman Cancer Center, San Pietro Hospital FBF ¶Unit of Neuroradiology, Sant’Andrea Hospital, Department of Neuroscience, Mental Health and Sense Organs, Sapienza University of Rome, Rome ∗∗Unit of Radiotherapy, Department of Medical, Surgical and Neuro Sciences, University of Siena, Siena ††IRCCS Neuromed, Pozzilli (IS), Italy. Received for publication December 14, 2019; revision accepted March 15, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Francesco Cicone, MD, PhD, Unit of Nuclear Medicine, Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, University Campus “Salvatore Venuta,” Viale Europa, 88100 Catanzaro, Italy. E-mail: firstname.lastname@example.org. Clinical Nuclear Medicine: July 2020 - Volume 45 - Issue 7 - p 557-558 doi: 10.1097/RLU.0000000000003070 Buy Metrics Abstract The differentiation between radiation-induced changes and tumor recurrence is a major pitfall of magnetic resonance imaging, which can be overcome by the use of PET. Although amino-acid PET tracers showed several advantages over 18F-fluorodeoxyglucose in neurooncology, studies comparing these 2 types of radiopharmaceuticals in previously irradiated brain metastases are lacking. Here, we demonstrated a mismatch between 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (F-DOPA) and FDG in the first report of a previously irradiated brain metastasis undergoing a longitudinal evaluation by sequential double tracer PET imaging. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.