Interesting ImagesIncidental Finding of Colon Carcinoma Related to High Uptake in 18F-PSMA-1007 PETArçay, Ayça MD∗,†; Eiber, Matthias MD∗; Langbein, Thomas MD∗Author Information From the ∗Department of Nuclear Medicine, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany †Department of Nuclear Medicine, Akdeniz University, Antalya, Turkey. Received for publication December 19, 2019; revision accepted March 19, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Ayça Arçay, MD, Department of Nuclear Medicine, Akdeniz University Hospital, Dumlupinar St 07059, Antalya, Turkey. E-mail: firstname.lastname@example.org. Clinical Nuclear Medicine: July 2020 - Volume 45 - Issue 7 - p 561-562 doi: 10.1097/RLU.0000000000003081 Buy Metrics Abstract We present a 78-year-old man with suspicion of prostate cancer due to a PSA of 200 ng/mL, who underwent 18F-PSMA-1007 (prostate specific membrane antigen) PET/CT for primary staging. Besides heterogeneous uptake to the prostate, an increased PSMA uptake in the cecum was observed, located in the thickened cecal wall with suspicion of a secondary malignancy. Colonoscopic biopsy followed by hemicolectomy confirmed the diagnosis of colon adenocarcinoma. This case demonstrates the importance of bioptic workup of suspicious findings on PSMA PET/CT, which are unlikely to be related to prostate cancer as PSMA ligand uptake is not exclusively prostate cancer specific. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.