Interesting Images18F-FDG PET/CT in Sporadic Creutzfeldt-Jakob DiseaseZizi, Ghali MD∗; Berger, Henri MD†; Lalire, Paul MD, MSc∗; Dejust, Sébastien MD∗; Morland, David MD, MSc∗,‡,§Author Information From the ∗Nuclear Medicine Department, Institut Godinot, Reims †Gastroenterology Department, CHIREC, Braine l’Alleud Hospital, Waterloo, Belgium ‡Laboratoire de biophysique, UFR de médecine §CReSTIC EA 3804, Université de Reims Champagne Ardenne, France. Received for publication October 31, 2019; revision accepted March 8, 2020. H.B. is a general practitioner. Conflicts of interest and sources of funding: none declared. Correspondence to: David Morland, MD, MSc, Médecine nucléaire, Institut Godinot, 1 rue du général Koenig, 51100 Reims, France. E-mail: firstname.lastname@example.org. Clinical Nuclear Medicine: July 2020 - Volume 45 - Issue 7 - p 538-539 doi: 10.1097/RLU.0000000000003059 Buy Metrics Abstract We report the case of a 64-year-old man referred for optic ataxia, constructional apraxia, and spatial orientation disorders evolving for 2 months. Benson syndrome (posterior cortical atrophy) was initially suspected. Brain 18F-FDG PET/CT depicted an asymmetric decreased uptake pattern consistent with Creutzfeldt-Jakob disease. 14-3-3 proteins were detected in the cerebrospinal fluid. Clinical evolution was quickly unfavorable. The patient died 1 month after the PET/CT, and Creutzfeldt-Jakob disease was confirmed on postmortem examination of brain tissue. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.