Interesting ImagesPrimary Central Nervous System Lymphoma With Diffuse Neurolymphomatosis Involving Multiple Cranial and Spinal Nerve RootsSingh, Shashank Shekhar DNB*; Mittal, Bhagwant Rai MD, DNB*; Kumar, Rajender MD*; Singh, Harmandeep MD*; Balaini, Neeraj MD†; Goyal, Manoj MD, DM†Author Information From the Departments of *Nuclear Medicine †Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Received for publication September 9, 2019; revision accepted February 7, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Bhagwant Rai Mittal, MD, DNB, Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education and Research, Nehru Hospital, A-Block, Ground Floor, Sector 12, Chandigarh 160012, India. E-mail: firstname.lastname@example.org. Online date: April 23, 2020 Clinical Nuclear Medicine: June 2020 - Volume 45 - Issue 6 - p e285-e287 doi: 10.1097/RLU.0000000000003018 Buy Metrics Abstract Primary central nervous system lymphoma is an extranodal lymphoma originating in the brain, spinal cord, and leptomeninges, which rarely spreads outside the nervous system. Neurolymphomatosis is the term used to describe lymphomatous involvement of the cranial nerves (except optic nerve) and peripheral nerve roots or plexus. We report a case of a 23-year-old man presented with progressive weakness of all 4 limbs. 18F-FDG PET/CT revealed FDG-avid thickening along the multiple cranial nerve roots, spinal nerve roots, and brain parenchymal lesion. Core biopsy from the peripheral nerve root demonstrated the lymphomatous involvement. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.