Interesting ImagesPearls and Pitfalls in Interpretation of 68Ga-DOTATOC PET ImagingBashir, Asma MD*; Broholm, Helle MD†; Clasen-Linde, Erik MD†; Vestergaard, Mark B. MSc, PhD*; Law, Ian MD, PhD, DMSc*Author Information From the Departments of *Clinical Physiology, Nuclear Medicine, and PET †Pathology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. Received for publication August 8, 2019; revision accepted February 10, 2020. Conflicts of interest and sources of funding: none declared. Author's contribution: A.B. contributed to the conception, design, and drafting of the manuscript. A.B. and I.L. contributed to the acquisition, analysis, and interpretation of the PET/CT data. H.B. and E.C.L. contributed to the neuropathological evaluation. A.B. and M.V. conducted full kinetic modeling using an image-derived input function. A.B., H.B., E.C.L., M.V., and I.L. contributed to the increase in the intellectual content and revision of the manuscript. Correspondence to: Asma Bashir, MD, Department of Clinical Physiology, Nuclear Medicine, and PET, Copenhagen University Hospital Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark. E-mail: email@example.com. Online date: April 23, 2020 Clinical Nuclear Medicine: June 2020 - Volume 45 - Issue 6 - p e279-e280 doi: 10.1097/RLU.0000000000003012 Buy Metrics Abstract DOTA-D-Phe1-Tyr3-octreotide labeled with 68Ga (68Ga-DOTATOC) is the commonly used PET tracer for imaging meningioma because of its high affinity to somatostatin receptor subtype 2 (SSTR2) and an established imaging modality for planning radiation and radionuclide therapy. However, SSTR2 is not an exclusive marker for meningioma, and not all meningiomas express high levels of SSTR2. The SSTR2 expression has been reported in other intracranial tumors, for example, glioma, pituitary adenoma, medullablastoma, primitive neuroectodermal tumors, and hemangioblastoma leading to a significant risk of misinterpretation of PET/CT findings. We present 2 cases with similar 68Ga-DOTATOC uptakes in 2 distinct etiologies, for example, cerebral lymphoma and meningioma. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.