Interesting ImagesIncreased Prostate-Specific Membrane Antigen Uptake in NeurofibromatosisWang, Yingwei MD*; Zeng, Cheng MD†; Liu, Huipan MD*; Chen, Yue MD*; Zhang, Wei MD, PhD*Author Information From the *Department of Nuclear Medicine, Affiliated Hospital of Southwest Medical University/Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou †Department of Radiology, Yibin First People’s Hospital, Yibin, Sichuan, People’s Republic of China. Received for publication November 27, 2019; revision accepted February 21, 2020. Conflicts of interest and sources of funding: none declared. Correspondence to: Wei Zhang, MD, PhD, Department of Nuclear Medicine, the Affiliated Hospital of Southwest Medical University, No. 25 TaiPing St, Jiangyang District, Luzhou, Sichuan, People’s Republic of China 646000. E-mail: firstname.lastname@example.org. Clinical Nuclear Medicine: June 2020 - Volume 45 - Issue 6 - p 465-467 doi: 10.1097/RLU.0000000000003039 Buy Metrics Abstract A 51-year-old man with 30-year neurofibromatosis and 2-month elevated prostate-specific antigen and back pain underwent a 68Ga–prostate-specific membrane antigen (PSMA) PET/CT scan for possible prostate cancer. Prostate-specific membrane antigen PET/CT imaging showed no abnormal uptake of the prostate. However, in addition to PSMA uptake in his left lung, thorax, and right ilium, which was confirmed being a lung squamous cell carcinoma by a lung biopsy, widespread uptake was also observed in his skin fibroma lesions. This case demonstrates that benign neurofibromatosis could have uptake of PSMA. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.