Interesting ImagesRare Esophageal Leptomeningeal Metastases Detected on 18F-FDG PET/CTLu, Yang MD, PhD*; Wang, Linghua MD, PhD†; Ajani, Jaffer A. MD‡Author Information From the Departments of *Nuclear Medicine †Genomic Medicine ‡Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX. Received for publication November 20, 2019; revision accepted December 3, 2019. Conflicts of interest and sources of funding: none declared. Correspondence to: Yang Lu, MD, PhD, Department of Nuclear Medicine Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, 1400 Pressler St, Unit 1483, Houston, TX 77030. E-mail: email@example.com. Online date: January 30, 2020 Clinical Nuclear Medicine: April 2020 - Volume 45 - Issue 4 - p 334-335 doi: 10.1097/RLU.0000000000002952 Buy Metrics Abstract A 62-year-old man with a history of locally advanced poorly differentiated adenocarcinoma of the gastroesophageal junction had received induction chemotherapy and concurrent chemoradiation. A 6-month follow-up FDG PET/CT revealed nearly resolved primary malignancy, but new hypermetabolic mediastinal lymph node metastasis and abnormal hypermetabolism in the cerebellum region. Brain MRI and lumbar puncture confirmed leptomeningeal metastasis. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.