Interesting ImagesIntense FAPI Uptake in Inflammation May Mask the Tumor Activity of Pancreatic Cancer in 68Ga-FAPI PET/CTLuo, Yaping MD*,†; Pan, Qingqing MD*,†; Zhang, Wen MD‡; Li, Fang MD*,†Author Information From the *Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital †Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine ‡Department of Rheumatology, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing, People's Republic of China. Received for publication October 11, 2019; revision accepted October 31, 2019. Conflict of interest and sources of funding: This work is supported by the CAMS Initiative for Innovative Medicine (CAMS-I2M, 2017-I2M-3-001). None declared to all authors. Correspondence to: Fang Li, MD, Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital; Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Wangfujing, Dongcheng District, Beijing 100730, People's Republic of China. E-mail: email@example.com. Online date: January 30, 2020 Clinical Nuclear Medicine: April 2020 - Volume 45 - Issue 4 - p 310-311 doi: 10.1097/RLU.0000000000002914 Buy Metrics Abstract Contrast CT revealed diffuse enlargement of the pancreas with a suspicious lesion in the uncinate process in a 57-year-old man who presented with jaundice. 18F-FDG PET/CT showed increased radioactivity in the enlarged pancreas with a nodular lesion with even higher uptake in the uncinate process. To differentiate autoimmune pancreatitis and pancreatic cancer, 68Ga-FAPI PET/CT was performed. It revealed intense 68Ga-FAPI uptake in the pancreas, but the FDG-avid lesion in the uncinate process was not shown. The patient was finally diagnosed with pancreatic cancer with tumor-induced pancreatitis with endoscopic ultrasonography–guided biopsy. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.