Interesting ImagesThe Great Mimicker—Tuberculosis Involving Prostate and Vertebrae Posing as Metastatic Prostate Carcinoma on FDG PET/CTJoshi, Prathamesh Vijay DRM, DNB*; Shewalkar, Balaji MD†; George, Thomas MD‡; Sahasrabudhe, Shrikant MD, IDCCM§; Joshi, Sujit MD∥; Kulkarni, Mukta DNB, DRM*Author Information From the *Department of Nuclear Medicine and PET/CT, Kamalnayan Bajaj Hospital †Department of Radiation Oncology, Government Cancer Hospital Departments of ‡Radiology §Critical Care, Kamalnayan Bajaj Hospital, Aurangabad ∥Excel Diagnostics, Pune, India. Received for publication June 8, 2019; revision accepted July 19, 2019. Conflicts of interest and sources of funding: none declared. This work was performed at Kamalnayan Bajaj Hospital, Aurangabad, India. Correspondence to: Prathamesh Joshi, DRM, DNB, Department of Nuclear Medicine and PET/CT, Kamalnayan Bajaj Hospital, Beed Bypass Rd, Aurangabad, Maharashtra 431010, India. E-mail: email@example.com. Online date: October 25, 2019 Clinical Nuclear Medicine: March 2020 - Volume 45 - Issue 3 - p 206-208 doi: 10.1097/RLU.0000000000002789 Buy Metrics Abstract A 65-year-old man underwent FDG PET/CT for evaluation of vertebral lesions, radiologically suspected to be metastases. The scan showed hypermetabolism in D8 to D9 vertebrae, retroperitoneal lymph nodes, and both the lobes of prostate. Transrectal ultrasound-guided biopsy of prostate was performed with suspicion of prostate malignancy. The biopsy revealed caseating granulomatous lesions in prostate suggestive of tuberculosis. Post antitubercular treatment patient showed excellent clinical response. Possibility of infective pathologies mimicking malignancy should be kept in mind while evaluating hypermetabolic foci seen on PET/CT. Although rare, tuberculosis of prostate needs consideration in differential diagnosis of FDG-avid foci seen in prostate. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.