Interesting ImagesAsymptomatic Metastasis to Thyroid Cartilage Detected by 18F-Choline and 64Cu-PSMA PET/CT as a Single Site of Disease Relapse in a Patient With Castration-Resistant Prostate CarcinomaAnnovazzi, Alessio MD, PhD*; Faiella, Adriana MD†; Pescarmona, Edoardo MD‡; Sanguineti, Giuseppe MD†; Sciuto, Rosa MD*Author Information From the *Nuclear Medicine Unit Departments of †Radiation Oncology ‡Pathology, IRCCS—Regina Elena National Cancer Institute, Rome, Italy. Received for publication July 4, 2019; revision accepted July 20, 2019. Conflicts of interest and sources of funding: none declared. Correspondence to: Alessio Annovazzi, MD, Nuclear Medicine Unit, IRCCS—Regina Elena National Cancer Institute Via Elio Chianesi, 53, 00144, Rome, Italy. E-mail: firstname.lastname@example.org. ORCID ID: 0000-0002-4887-7982 Online date: October 25, 2019 Clinical Nuclear Medicine: March 2020 - Volume 45 - Issue 3 - p 214-216 doi: 10.1097/RLU.0000000000002786 Buy Metrics Abstract Metastatic involvement of the larynx is rare due to the absence of vessels within the cartilaginous tissue. The probability of metastatic spread increases with aging as a result of larynx ossification. The secondary involvement of larynx is more frequently associated with melanoma and renal cell carcinoma. Few observations have been reported also in prostate cancer patients, usually associated with advanced disease and diffuse metastatic bone involvement. We report a case of an 83-year-old man with castration-resistant prostate cancer in whom a metastasis to the thyroid cartilage was the only site of relapse. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.