Interesting ImagesComplete Spontaneous Regression of Hepatosplenic T-Cell Lymphoma After Surgical BiopsyNakamoto, Ryusuke MD, PhD*; Okuyama, Chio MD, PhD†; Oka, Satoshi MD, PhD‡Author Information From the *Department of Radiology, Shiga General Hospital †Division of PET Imaging, Shiga Medical Center Research Institute ‡Department of Hematology and Oncology, Shiga General Hospital, Moriyama, Japan. Received for publication May 18, 2019; revision accepted July 18, 2019. Conflicts of interest and sources of funding: none declared. Correspondence to: Ryusuke Nakamoto, MD, PhD, Shiga General Hospital, 5-4-30, Moriyama, Shiga 524-8524, Japan. E-mail: email@example.com. Online date: October 25, 2019 Clinical Nuclear Medicine: February 2020 - Volume 45 - Issue 2 - p e88-e91 doi: 10.1097/RLU.0000000000002782 Buy Metrics Abstract 18F-FDG PET/CT for a 74-year-old man with elevated serum soluble interleukin 2 receptor showed multiple intense uptake in the liver, spleen, and bone. A surgical biopsy from 2 of liver tumors confirmed hepatosplenic αβ T-cell lymphoma. One and a half months after biopsy, FDG PET scan was performed again for staging before starting chemotherapy, and it showed the complete disappearance of all of the lesions. The excisional biopsy could be a possible trigger of his spontaneous regression. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.