Interesting Images68Ga-PMSA Uptake in the Lung Metastatic Versus Primary Lung TumorUsmani, Sharjeel MBBS, MS, FEBNM, CBNC*,†; Sadeq, Alya'a MBBS†; Marafi, Fahad KBNM*; Esmail, Abdulredha KBNM*; al Kandari, Fareeda KBNM†; Ahmed, Najeeb FRCR, FRCP*Author Information From the *Nuclear Medicine Department, Jaber Al-Ahmad Molecular Imaging Center, Kuwait City †Nuclear Medicine Department, Kuwait Cancer Control Center, Khaitan, Kuwait. Received for publication May 14, 2019; revision accepted September 28, 2019. Conflicts of interest and sources of funding: none declared. Correspondence to: Sharjeel Usmani, MBBS, MS, FEBNM, CBNC, Department of Nuclear Medicine, Kuwait Cancer Control Center, PO Box 1488, 83001 Khaitan, Kuwait. E-mail: firstname.lastname@example.org. Online date: December 24, 2019 Clinical Nuclear Medicine: February 2020 - Volume 45 - Issue 2 - p e80-e82 doi: 10.1097/RLU.0000000000002870 Buy Metrics Abstract 68Ga-PSMA is a promising tracer for both primary staging and detection of biochemical recurrence in prostate cancer. PSMA is also expressed in the neovascular endothelium of various solid malignancies possibly due to tumor-associated angiogenic factors and endothelial cell sprouting. We report a case of a 73-year-old man of prostate cancer with rising prostate-specific antigen levels. 68Ga-PSMA PET/CT was performed, which showed a focal lung lesion, with subsequent histological confirmation of adenocarcinoma of the lung. Incidental lung lesions on 68Ga-PSMA in prostate cancer patients should elicit a differential of primary lung malignancy, especially if clinical and morphological suspicion is high. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.