Interesting Images18F-FDG PET/CT in a Patient With Thymoma-Associated Paraneoplastic PolymyositisFu, Zhanli MD*; Chen, Guoqian MD†; Chen, Xueqi PhD, MD*; Li, Qian MD‡Author Information From the *Department of Nuclear Medicine, Peking University First Hospital, Beijing †Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China ‡Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Received for publication July 31, 2019; revision accepted October 15, 2019. Z.F. and G.C. contribute equally to this case report. Conflicts of interest and sources of funding: none declared. Correspondence to: Zhanli Fu, MD, Department of Nuclear Medicine, Peking University First Hospital, No. 8, Xishiku St, West District, Beijing 100034, China. E-mail: email@example.com. Online date: December 24, 2019 Clinical Nuclear Medicine: February 2020 - Volume 45 - Issue 2 - p 148-150 doi: 10.1097/RLU.0000000000002899 Buy Metrics Abstract A 43-year-old woman presented with progressive muscle weakness and myalgia for 1 month. Laboratory tests revealed the elevation of myogenic enzymes. MRI of the thighs demonstrated a pattern of edema for inflammatory myopathy. Electromyography showed diffuse myopathic disorder, and muscle biopsy indicated polymyositis. 18F-FDG PET/CT was performed to investigate the potential paraneoplastic syndrome and revealed a soft tissue lesion with 18F-FDG avidity in the right anterior mediastinum, as well as diffusely increased activity throughout the body muscles. The patient's symptoms and biochemical abnormalities were gradually relieved after the tumor resection, and the histopathology indicated a type AB thymoma. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.