Interesting Images18F-FDG PET/CT-Guided Diagnosis and Evaluation of Treatment Response to Cyclosporine A in Maldistributed Subcutaneous Panniculitis-like T-Cell Lymphoma Without Typical Skin RashAbe, Yoshiaki MD; Narita, Kentaro MD; Kobayashi, Hiroki MD; Kitadate, Akihiro MD, PhD; Takeuchi, Masami MD; Matsue, Kosei MD, PhDAuthor Information From the Division of Hematology/Oncology, Department of Internal Medicine, Kameda Medical Center, Kamogawa, Japan. Received for publication March 22, 2019; revision accepted September 23, 2019. Y.A. and K.N. contributed equally to this work. Conflicts of interest and sources of funding: none declared. Correspondence to: Yoshiaki Abe, MD, Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, 929 Higashi-chou, Kamogawa, Chiba 296-8602, Japan. E-mail: email@example.com. Online date: December 11, 2019 Clinical Nuclear Medicine: February 2020 - Volume 45 - Issue 2 - p e69-e71 doi: 10.1097/RLU.0000000000002863 Buy Metrics Abstract A 30-year-old woman presented with persistent fever and elevated lactate dehydrogenase levels without skin rash. 18F-FDG PET/CT revealed FDG uptake in subcutaneous tissues in the forearm, buttocks, and lower limbs, whereas the trunk was unaffected. She was diagnosed with subcutaneous panniculitis-like T-cell lymphoma based on a PET/CT-guided subcutaneous tissue biopsy from the thigh. Although conventional cytotoxic agent–based chemotherapies failed to achieve disease remission, subsequent cyclosporine A treatment promptly resolved the fever and laboratory abnormalities. Remarkably, abnormal FDG uptake disappeared entirely on follow-up PET/CT, demonstrating its utility in the evaluations of responses to emerging cyclosporine A–based treatments in subcutaneous panniculitis-like T-cell lymphoma. Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.