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Uptake of 18F-Fluciclovine in Paget Disease

Akin-Akintayo, Oladunni O. MD, MPH*; Bonta, Dacian MD, PhD*,†; Barron, Bruce MD, MHA*,†

doi: 10.1097/RLU.0000000000002670
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Since its recent approval by the United States Food and Drug Administration, fluciclovine PET-CT has gained widespread use for imaging of recurrent prostate cancer patients. As an amino acid–based radiotracer transported by LAT-1 and ASCT-2 transporters, fluciclovine exploits the up-regulation of amino acid transporters in malignant cells. We present a rare case of fluciclovine uptake in Paget disease in a 58-year-old man with suspected recurrent prostate cancer and asymmetric increased left hemipelvic uptake on imaging.

From the *Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University

Veterans Administration Medical Center, Atlanta, Georgia.

Received for publication March 16, 2019; revision accepted May 3, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Oladunni Akin-Akintayo, MD, MPH, Division of Nuclear Medicine, Department of Radiology and Imaging Sciences, Emory University School of Medicine, 1364 Clifton Rd, Atlanta, Georgia 30322. E-mail:

Online date: July 8, 2019

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