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Influence of Biological Parameters Assessed in [18F]FDG PET/CT on Overall Survival in Cervical Cancer Patients

Cegla, Paulina PhD*; Burchardt, Ewa MD, PhD; Roszak, Andrzej MD, PhD†,‡; Czepczynski, Rafal MD, PhD§; Kubiak, Anna MSc; Cholewinski, Witold MD, PhD*,‡

doi: 10.1097/RLU.0000000000002733
Original Articles
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Aim The aim of this study was to estimate the influence of biological parameters assessed in [18F]FDG PET/CT on overall survival (OS) in cervical cancer patients.

Methods Retrospective analysis was performed on a group of 371 patients with newly diagnosed and histologically confirmed cervical cancer. PET biological parameters in primary tumor including SUVmax, SUVmean, total lesion glycolysis (TLG), metabolic tumor volume (MTV), heterogeneity, and parameters referring both to primary tumor and metastatic lesions: SUVtotal, TLGtotal, and MTVtotal, were analyzed.

Results Based on PET/CT results, 3 subgroups were identified: cervical only—with disease limited only to the cervix (38%), +regional nodes—where increased glucose accumulation in addition to the cervical area was also observed in regional lymph nodes (36%), and +distal metastases—where PET scan showed a disseminated disease (26%). Depending on the stage of the disease, in the cervical-only group, 5-year survival rate was 86%; in the +regional nodes group, it was 80%; whereas in the +distal metastases group, 5-year survival rate was only 55%. However, based on Cox regression model, significant influence on OS was found only in heterogeneity of primary tumor; more inhomogeneous tumors suggest worse prognosis (0.25 ± 0.04 vs 0.16 ± 0.09, P < 0.001), SUVtotal (76.6 ± 130.1 vs 45.4 ± 73.4, P = 0.002), and MTVtotal (79.03 ± 88.27 vs 63.00 ± 83.80 cm3, P = 0.03). For heterogeneity, cutoff point suggesting worse prognosis was 0.18; for SUVtotal, 52.3; and for MTVtotal, 66.55 cm3.

Conclusions Stage of disease assessed in [18F]FDG PET/CT significantly influences survival rate in patients with cervical cancer. SUVtotal, MTVtotal, and heterogeneity of primary tumor are independent prognostic factors on OS in cervical cancer patients.

From the Departments of *Nuclear Medicine

Radiotherapy and Gynaecological Oncology, Greater Poland Cancer Centre

Chair and Department of Electroradiology, Medical University in Poznan

§Department of Endocrinology, Metabolism and Internal Medicine University of Medical Science

Greater Poland Cancer Registry, Greater Poland Cancer Centre, Poznan, Poland.

Received for publication March 25, 2019; revision accepted June 2, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Paulina Cegla, PhD, Department of Nuclear Medicine, Greater Poland Cancer Center, Garbary 15, 61-866 Poznan, Poland. E-mail: paulina.cegla@gmail.com.

Online date: July 25, 2019

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