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Heat-Damaged Red Blood Cell Scintigraphy in Helping Interpretation of 68Ga-DOTATATE PET/CT

Wen, Zhe MD, PhD*,†; Edwards, Kevin W. BSRT(N)(R), CNMT(PET); States, Lisa J. MD; Zhuang, Hongming MD, PhD, FACNM

doi: 10.1097/RLU.0000000000002730
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68Ga-DOTATATE PET/CT was performed to determine the cause of endogenous Cushing syndrome in a 10-year-old boy whose MRI studies did not reveal pituitary or adrenal gland abnormality. The PET/CT images demonstrated an intense activity in a small soft tissue nodule in the left upper abdomen where splenules are commonly located. Heat-damaged 99mTc-labeled red blood cell imaging showed that this soft tissue nodule did not have increased red blood cell activity, which indicated that this lesion was a true somatostatin receptor–rich lesion. The pathology result following surgical resection of the lesion confirmed adrenocorticotropic hormone–producing neuroendocrine tumor.

From the *Department of Nuclear Medicine, Beijing Shijitan Hospital, Capital Medical University, Beijing, People's Republic of China

Department of Radiology Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Received for publication May 28, 2019; revision accepted June 4, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Kevin W. Edwards, BSRT(N)(R), CNMT(PET), Nuclear Medicine, Department of Radiology, The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, 34th & Civic Ctr Blvd, Philadelphia, PA 19104. E-mail: Edwardsk@email.chop.edu.

Online date: July 15, 2019

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