Rosai-Dorfman disease, also known as sinus histiocytosis with massive lymphadenopathy, is a rare nonneoplastic histiocytic disorder that often involves the lymph nodes and occasionally the central nervous system or skeleton. However, the presence of extranodal Rosai-Dorfman lesions without lymphadenopathy is extremely rare. Here we present a case of a pathological confirmed Rosai-Dorfman disease with pituitary and skeletal involvement without lymph nodes involvement.
From the Departments of *Neurosurgery
†Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Received for publication March 2, 2019; revision accepted July 13, 2019.
Conflicts of interest and sources of funding: This study was funded by the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (grant no. 2016-I2M-2-001 and no. 2018-I2M-3-001) and the Fundamental Research Funds for the Central Universities (Grant No. 3332018029). None declared to all authors.
Correspondence to: Xin Cheng, MD, Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, China. E-mail: email@example.com.