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A Novel Application of [18F]Fluorothymidine-PET ([18F]FLT-PET) in Clinical Practice to Quantify Regional Bone Marrow Function in a Patient With Treatment-Induced Cytopenias and to Guide “Marrow-Sparing” Radiotherapy

Campbell, Belinda A. FRANZCR*; Hofman, Michael S. FAANMS; Prince, H. Miles MD

doi: 10.1097/RLU.0000000000002785
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18F-Fluorothymidine-positron emission tomography with CT fusion ([18F]FLT-PET/CT) offers a unique and non-invasive method for three-dimensional localization and quantification of functional bone marrow. [18F]FLT-PET/CT has potential application in radiotherapy planning when risk of marrow toxicity is a significant clinical concern. In this patient with chemo-refractory, transformed lymphoma and treatment-induced cytopenias, [18F]FLT-PET/CT was a novel and useful adjunct to (1) image the distribution of functional bone marrow reserve, (2) guide “marrow-sparing” radiotherapy planning, and (3) quantify the effects of radiotherapy-induced bone marrow suppression both in-field and out-of-field.

From the *Department of Radiation Oncology

Centre of Molecular Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria

Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.

Received for publication March 24, 2019; revision accepted July 21, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Belinda A. Campbell, Peter MacCallum Cancer Centre, Locked Bag 5, A’Beckett St, Melbourne, Victoria 8006, Australia. E-mail: belinda.campbell@petermac.org.

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