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Nivolumab-Induced Pneumonitis in Patient With Metastatic Melanoma Showing Complete Remission on 18F-FDG PET/CT

Razzouk-Cadet, Micheline MD*; Picard, Alexandra MD; Grangeon-Chapon, Caroline PharmD*,‡; Lacour, Jean-Philippe MD, PhD†,§; Montaudié, Henri MD, PhD†,§

doi: 10.1097/RLU.0000000000002707
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A 49-year-old patient with metastatic melanoma was treated with nivolumab (Opdivo). An early 18F-FDG PET/CT after 2 cycles showed a progressive metabolic disease. A 4-month optimal follow-up 18F-FDG PET/CT showed a complete metabolic response. The treatment was stopped after 22 cycles because of immunotherapy-related pneumonitis. After discontinuation of treatment, PET/CT examinations demonstrated a metabolic complete remission during 2 years. The metabolic pattern on early PET was suggestive of pseudoprogression, which is a rare phenomenon reflecting an activation of inflammatory cells within the tumor microenvironment causing lesions to increase in size and to accumulate FDG until a sufficient immune response is developed.

From the Departments of *Nuclear Medicine


Pharmacy, CHU Nice

§INSERM, U1065, Équipe 12 C3M, Nice, France.

Received for publication March 13, 2019; revision accepted May 29, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Micheline Razzouk-Cadet, MD, Department of Nuclear Medicine, Centre Hospitalier Universitaire de Nice, Archet, 151, Route de Saint-Antoine de Ginestière 06200 Nice Cedex 3, France. E-mail:

Online date: July 15, 2019

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