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Isolated Muscular Sarcoidosis Revealed by Hypercalcemia and 18F-FDG PET/CT

Dhomps, Anthony MD*; Foret, Thibault MD*; Streichenberger, Nathalie MD; Skanjeti, Andrea MD, PhD; Tordo, Jeremie MD*

doi: 10.1097/RLU.0000000000002678
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A 43-year-old woman, with previous history of renal lithiasis, was admitted on an emergency for severe hypercalcemia fortuitously discovered in a context of rapidly progressive kidney failure. An 18F-FDG PET/CT performed to rule out underlying malignancy revealed an intense diffuse and isolated muscular FDG uptake with fascia infiltration on the CT finding. A muscular biopsy was performed and demonstrated a non-necrosing granuloma with multinucleated giant cells consistent with muscular sarcoidosis. A corticotherapy was started with a rapid normalization of serum calcium level. The follow-up 18F-FDG PET/CT 4 months later showed a complete response of the sarcoidosis myositis.

From the *Nuclear Medicine Department, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon

Department of Pathology, Centre Hospitalier Lyon Sud

Nuclear Medicine Department, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Pierre-Benite, France.

Received for publication March 20, 2019; revision accepted May 8, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Jeremie Tordo, MD, Nuclear Medicine department, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Pierre-Benite, France. E-mail:

Online date: July 5, 2019

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