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Heterogeneity of 68Ga-PSMA PET/CT Uptake in Fibrous Dysplasia

Plouznikoff, Nicolas MD, PhD*,†; Garcia, Camilo MD; Artigas, Carlos MD*; Entezari, Kim MD§; Flamen, Patrick MD, PhD*

doi: 10.1097/RLU.0000000000002609
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Fibrous dysplasia is an uncommon benign bone pathology with only rare potential for malignant transformation. We describe the heterogeneous uptake of fibrous dysplasia of a whole rib on 68Ga-labeled prostate-specific membrane antigen (PSMA) PET/CT. 68Ga-PSMA binds to PSMA-expressing prostate cancer cells, but it can also bind to the neovasculature of various solid tumors, as well as to some benign lesions. 68Ga-PSMA expression in fibrous dysplasia should not automatically be equated with malignant transformation or confused with prostate cancer metastases.

From the *Department of Nuclear Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium

Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada

Departments of Nuclear Medicine

§Urology, Centre Hospitalier Universitaire Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.

Received for publication March 6, 2019; revision accepted March 23, 2019.

Contributions: Dr Plouznikoff followed up on the PET/CT, reviewed the patient's medical records, and drafted the manuscript. Dr Garcia initially read the PET/CT. Dr Artigas acted as an expert consultant for the case and revised the manuscript. Dr Entezari clinically followed the patient. Dr Flamen revised the manuscript for important intellectual content.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Nicolas Plouznikoff, MD, PhD, Service de Médecine Nucléaire, Centre Hospitalier de l'Université de Montréal, 1051 Rue Sanguinet, Montréal, Quebec H2X 0C1, Canada. E-mail: nicolas.plouznikoff@umontreal.ca.

Online date: May 3, 2019

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