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Use of 18F-Fluciclovine to Diagnose Recurrent Prostate Carcinoma in a Patient With Beta-Thalassemia

Schmitt, Chelsea R. MS*; Schmitt, Christian T. MD; Hinds, Peter R. MD; Sawyer, Kevin J. MD

doi: 10.1097/RLU.0000000000002719
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We present a case demonstrating increased diagnostic difficulty in interpretation of 18F-flucyclovine PET/CT in a patient with beta-thalassemia. 18F-flucyclovine PET/CT demonstrated diffuse increased marrow activity. Additional findings of extramedullary hematopoiesis including intrasplenic extramedullary hematopoiesis are presented. Despite the background marrow activity, an osseous metastatic lesion representing recurrent metastatic prostate carcinoma was identified. This case demonstrates a spectrum of findings of 18F-flucyclovine uptake in thalassemia, which increased the difficulty of identifying recurrent disease.

From the *University of South Florida Morsani College of Medicine, Tampa

Radiology and Imaging Specialists

Hollis Cancer Center, Lakeland Regional Health, Lakeland, FL.

Received for publication February 15, 2019; revision accepted June 2, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Chelsea R. Schmitt, MS, Radiology and Imaging Specialists of Lakeland, 2125 Crystal Grove Dr, Lakeland, FL 33801. E-mail:

Online date: July 8, 2019

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