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Nivolumab-Associated Pulmonary and Bone Sarcoidosis in a Patient With Melanoma of Unknown Primary

Tulbah, Rima I. MD; Rowe, Steven P. MD, PhD; Solnes, Lilja B. MD, MBA; Javadi, Mehrbod S. MD

doi: 10.1097/RLU.0000000000002724
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A 57-year-old man with stage IIIB malignant melanoma of unknown primary presented for pretherapy FDG PET/CT that demonstrated metastatic left cervical lymph node with no other site of involvement. Following left neck dissection, nivolumab was initiated. Follow-up FDG PET/CT 3 months after initiation of nivolumab demonstrated extensive radiotracer-avid chest lymphadenopathy and multiple bone lesions. Ultrasound-guided endobronchial biopsy of the mediastinal lymph nodes demonstrated sarcoidosis.

From the Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.

Received for publication August 30, 2018; revision accepted June 2, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Mehrbod S. Javadi, MD, Division of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Johns Hopkins Outpatient Center, Room 3235, 601 N Caroline St, Baltimore, MD 21287. E-mail: mjavadi@jhmi.edu.

Online date: July 25, 2019

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