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Isolated Involvement of Prostate Gland by Immunoglobulin G4–Related Disease Diagnosed With the Help of FDG PET/CT

Vankadari, Kousik DNB*; Mittal, Bhagwant Rai MD, DNB*; Kumar, Rajender MD*; Singh, Harmandeep MD*; Bhattacharya, Anish DNB, PhD*; Kochhar, Rakesh MD, DM

doi: 10.1097/RLU.0000000000002689
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Immunoglobulin G4 (IgG4)–related disease is known to mimic multiple malignancies and always poses a diagnostic challenge. We report a case of a 20-year-old young man, who presented with unexplained recurrent episodes of fever and pain abdomen. 18F-FDG PET/CT revealed intense focal FDG avidity in the prostate. On further workup, he had an elevated serum IgG4 level, and a clinical diagnosis of immunoglobulin G4–related disease was kept. A follow-up FDG PET/CT after glucocorticoid therapy revealed resolution of FDG avidity in the prostate with fall in serum IgG4 levels, hence confirming a diagnosis of atypical immunoglobulin G4–related disease involving isolated prostate gland.

From the Departments of *Nuclear Medicine and PET/CT

Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Received for publication January 14, 2019; revision accepted May 18, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Bhagwant Rai Mittal, MD, DNB, Department of Nuclear Medicine and PET, A Block, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India. E-mail:

Online date: July 8, 2019

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