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Incidental Finding of Acute Lymphocytic Leukemia in a Prostate-Specific Membrane Antigen PET/CT

Acksteiner, Christian Dr Med, FRANZCR; Sounness, Brett MBBS, FRANZCR

doi: 10.1097/RLU.0000000000002712
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PSMA PET/CT is known to show uptake in various benign and malignant processes. The following PSMA PET/CT was performed for prostate carcinoma staging (Gleason 3 + 4 left apex; PSA 5.8). It shows incidental diffuse PSMA marrow uptake, not typical for prostate metastatic disease. No treatment had been commenced at the time of the scan. Serology and bone marrow biopsy showed B-cell acute lymphocytic leukemia. Focal PSMA uptake in the right ischium was correlated with a T1 hypointense lesion on a previous MRI and was convincing for a skeletal metastasis. Alternative diagnoses in diffuse skeletal PSMA uptake need therefore to be considered.

From the South Coast Radiology, Varsity Lakes, Queensland, Australia.

Received for publication December 27, 2018; revision accepted May 31, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Christian Acksteiner, Dr Med, FRANZCR, South Coast Radiology, Locked Bag 1000, Mermaid Beach, Queensland 4218 Australia. E-mail:

Online date: July 15, 2019

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