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High-Resolution PET Cisternography With 64Cu-DOTA for CSF Leak Detection

Freesmeyer, Martin MD*; Schwab, Matthias MD; Besteher, Bianca MD†,‡; Gröber, Sebastian MSc*; Waschke, Albrecht MD, MBA§; Drescher, Robert MD, MA*

doi: 10.1097/RLU.0000000000002695
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Intracranial hypotension may lead to chronic, debilitating symptoms, and severe complications. The underlying CSF leak may be difficult to localize. To establish a new diagnostic option for the detection of CSF leaks, 64Cu-DOTA was developed as a tracer for PET imaging. PET/CT imaging was possible with high resolution and without complications. In one patient, the exact site of a dural tear was identified, enabling successful surgical treatment. PET cisternography with 64Cu-DOTA appears to be safe and able to locate a CSF leak. It has the potential to be a problem-solving modality in cases with inconclusive CT, MR, and/or scintigraphic findings.

From the Clinics of *Nuclear Medicine


Psychiatry and Psychotherapy

§Neurosurgery, Jena University Hospital, Jena, Germany.

Received for publication February 8, 2019; revision accepted May 19, 2019.

Conflicts of interest and sources of funding: none declared.

Correspondence to: Martin Freesmeyer, MD, Clinic of Nuclear Medicine, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany. E-mail:

Online date: July 5, 2019

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